Voprosy meditsinskoi khimii (ISSN 0042-8809)

Degradation of thiamine diphosphate in subcellular fractions of mouse liver in the dynamics of the development of alimentary B1-avitaminosis

   
Tumanov V.N., Trebukhina R.V.
PubMed Id: 6623999
Year: 1983 vol: 29  issue:4  pages: 99-102
Abstract: Alterations in activity of specific and unspecific phosphatases, hydrolyzing thiamin diphosphate, were studied in microsomes, mitochondria and cytosol of mice liver cells in dynamics of alimentary B1-avitaminosis (4-21 days). Activity of the enzymes studied was increased as thiamin deficiency developed. Administration of thiamin into the avitaminous animals normalized the enzymatic activity, indicating the specific dependence of these alterations on the thiamin level in animal tissue.
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Reference: Tumanov V.N., Trebukhina R.V., Degradation of thiamine diphosphate in subcellular fractions of mouse liver in the dynamics of the development of alimentary B1-avitaminosis, Voprosy meditsinskoi khimii, 1983, vol: 29(4), 99-102.
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