Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of retardation of fibrin polymerization using a thermostable inhibitor from human serum

   
Byshevskii A.Sh., Chiriat'ev E.A.
PubMed Id: 6649529
Year: 1983 vol: 29  issue:5  pages: 22-27
Abstract: A purified thermostable inhibitor of fibrin polymerization was found to have a molecular mass of 1,750 +/- 100 daltons. Early steps of the fibrin polymerization were the most sensitive to the effect of this inhibitor; less distinct but constant activity was exhibited by the inhibitor at later steps of the process. As shown by kinetics of inhibition the inhibitor reacted with fibrin-monomer as well as with more complex products of polymerization but the final products (unstabilized fibrin) did not contain this substance. The inhibitor was found in a number of tissues. The inhibitor appears to be responsible for long-term existence of fibrin-monomer in circulation.
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Reference: Byshevskii A.Sh., Chiriat'ev E.A., Mechanism of retardation of fibrin polymerization using a thermostable inhibitor from human serum, Voprosy meditsinskoi khimii, 1983, vol: 29(5), 22-27.
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