Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of prostaglandins F2 and F2 alpha on the pentosephosate pathway in human blood platelets

   
Makarov S.A., Kudriavtseva G.V., Kolotilova A.I.
PubMed Id: 6316661
Year: 1983 vol: 29  issue:5  pages: 27-32
Abstract: Rates of glucose-6-phosphate oxidation and formation of sedoheptulose-7-phosphate were increased after 10 min preincubation of human blood platelets with prostaglandins F2 and F2a. When the preincubation was prolonged up to 60 min, the prostaglandins activating effect was manifested only as an increase in sedoheptulose-7-phosphate content. Preincubation of thrombocytes with dibutyryl-cAMP led to an increase in the rate of ribose-5-phosphate consumption as well as of sedoheptulose-7-phosphate formation. Chlorpromazine hydrochloride decreased the rates of glucose-6-phosphate and 6-phosphogluconate oxidation in extracts of human thrombocytes and inhibited the activating effect of prostaglandins on sedoheptulose-7-phosphate formation.
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Reference: Makarov S.A., Kudriavtseva G.V., Kolotilova A.I., Effect of prostaglandins F2 and F2 alpha on the pentosephosate pathway in human blood platelets, Voprosy meditsinskoi khimii, 1983, vol: 29(5), 27-32.
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