Voprosy meditsinskoi khimii (ISSN 0042-8809)

Functioning of the oxidizing phase of the pentosephosphate pathway in rat liver in the development of vitamin B1 deficiency in the animals

   
Gorbach Z.V., Maglysh S.S., Kubyshin V.L.
PubMed Id: 6649530
Year: 1983 vol: 29  issue:5  pages: 36-41
Abstract: B1-hypovitaminosis was simulated in white rats of 150-170 g body mass by means of hydroxythiamin administration at a daily dose of 4, 40 or 100 mg/kg within 10 days. Concentrations of NADP and NADPH, main cofactors of 6-phosphogluconate dehydrogenase, were dissimilarly altered in the animal liver tissue depending on the antimetabolite dose administered. Kinetic characteristics of 6-phosphogluconate dehydrogenase isozymes were shifted towards more active binding of substrates in the hypovitaminosis. Total pool of metabolites, realized via 6-phosphogluconate dehydrogenase catalytic reactions and regulated by concentration of substrates, was especially sensitive to alterations in the NADP/NADPH ratio. In severe B1-hypovitaminosis caused by hydroxythiamin the rate of oxidative reactions was increased 3-10-fold.
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Reference: Gorbach Z.V., Maglysh S.S., Kubyshin V.L., Functioning of the oxidizing phase of the pentosephosphate pathway in rat liver in the development of vitamin B1 deficiency in the animals, Voprosy meditsinskoi khimii, 1983, vol: 29(5), 36-41.
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