Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of M-and N-cholinolytics on the content of Ca2+ in synaptosomes and metabolism of phosphoinositols in the rat brain

   
Sukhovskaia T.A., Semenov E.V., Krylov S.S.
PubMed Id: 6649533
Year: 1983 vol: 29  issue:5  pages: 51-54
Abstract: M-cholinolytics benactyzine and glypine increased a permeability of neurone membranes for Ca2+, producing the ion accumulation in synaptosomes. N-cholinolytic thropacin did not exhibit this effect and diphacyl caused similar to the M-cholinolytics but only slight effect on the Ca2+ content. The M-cholinolytics increased phosphoinositol turnover in rat brain, while the N-cholinolytics decreased its metabolism. These data obtained suggest that the M-cholinolytics interact selectively with phosphoinositols of neurone membranes affecting the affinity of phosphoinositols to two-valent cations and elevating the ability of Ca2+ to penetrate across neuronal membranes.
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Reference: Sukhovskaia T.A., Semenov E.V., Krylov S.S., Effect of M-and N-cholinolytics on the content of Ca2+ in synaptosomes and metabolism of phosphoinositols in the rat brain, Voprosy meditsinskoi khimii, 1983, vol: 29(5), 51-54.
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