Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of chromogenic substrates for estimation of indicators of kallikrein-kinin and blood coagulation systems in blood plasma of patients with nephrotic syndrome

   
Baskova I.P., Paskhina T.S., Poliantseva L.R., Iakubovskaia R.I., Tiero A.A.
PubMed Id: 6557709
Year: 1983 vol: 29  issue:5  pages: 96-99
Abstract: A distinct increase of kallikrein content in blood plasma of patients with nephrotic syndrome as well as activation of thrombin simultaneously with a decrease in the prothrombin level were recorded in samples with synthetic chromogenic substrates S-2160 (Bz-Phe-Val-Arg-pNa), S-2238 (D-Phe-Pip-Arg-pNA) and S-2302 (D-Pro-Phe-Arg-pNA). Limited proteolysis of prothrombin by blood plasma kallikrein appears to be among the possible reasons of thrombin activation in the patients with nephrotic syndrome. Activity of plasmin, measured with S-2251 (D-Val-Leu-Lys-pNA) as a chromogenic substrate, was practically unlatered in blood plasma of these patients.
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Reference: Baskova I.P., Paskhina T.S., Poliantseva L.R., Iakubovskaia R.I., Tiero A.A., Use of chromogenic substrates for estimation of indicators of kallikrein-kinin and blood coagulation systems in blood plasma of patients with nephrotic syndrome, Voprosy meditsinskoi khimii, 1983, vol: 29(5), 96-99.
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