Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of mediators in the genesis of convulsive activity. Biogenic monoamine content of the brain of rats with various predispositions to audiogenic convulsions

   
Sergienko N.G., Loginova G.A.
PubMed Id: 6142564
Year: 1983 vol: 29  issue:6  pages: 21-24
Abstract: Content of serotonin, tryptophane, adrenaline, noradrenaline, dopamine, DOPA and tyrosine in was studied in cerebellum, truncus cerebri, hypothalamus and brain hemispheres of rats with various predisposition to audiogenic convulsions. Distinct decrease in content of brain serotonin, noradrenaline and increase in dopamine content was noted in rats with high level of audiogenic convulsive activity. The data obtained suggest that the increase in dopamine and decrease in serotonin and noradrenaline content in brain tissue may be among the factors responsible for elevation of potential convulsive activity of central nervous system.
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Reference: Sergienko N.G., Loginova G.A., The role of mediators in the genesis of convulsive activity. Biogenic monoamine content of the brain of rats with various predispositions to audiogenic convulsions, Voprosy meditsinskoi khimii, 1983, vol: 29(6), 21-24.
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