Voprosy meditsinskoi khimii (ISSN 0042-8809)

Diurnal changes in the lysosomal enzyme activity of the liver of mice and rats

   
Blinova T.V., Zharikova G.V., Kovalenko I.A., Kosykh A.A.
PubMed Id: 6422629
Year: 1983 vol: 29  issue:6  pages: 27-30
Abstract: Lysosomal enzymes acid phosphatase, acid DNAase, acid RNAase cathepsin D,beta-galactosidase beta-glucuronidase were studied in mice and rat liver tissue within 3 days beginning from 4 o'clock a.m. at 4 hrs intervals. Activities of acid phosphatase, acid RNA ase in mice liver tissue and of cathepsin D in rat and mice liver tissues was higher at morning and day time than at evening and night. Alterations in enzymatic activity of non-sedimenting fraction of mice liver tissue correlated with that of total activity. In non-sedimenting fraction of rat liver tissue the enzymatic activity was altered only slightly. Within the second half of a day the enzymatic activity redistributed in the cells with an increase of the activity in non-sedimenting fraction, caused by labilization of lysosomal membranes.
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Reference: Blinova T.V., Zharikova G.V., Kovalenko I.A., Kosykh A.A., Diurnal changes in the lysosomal enzyme activity of the liver of mice and rats, Voprosy meditsinskoi khimii, 1983, vol: 29(6), 27-30.
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