Voprosy meditsinskoi khimii (ISSN 0042-8809)

Proteinase inhibitor activity of blood plasma and cerebrospinal fluid in patients with pituitary adenomas before and after proton therapy

   
Zargarova O.P., Konnova L.A.
PubMed Id: 6199897
Year: 1983 vol: 29  issue:6  pages: 96-98
Abstract: 35 patients with somatotropic adenoma of hypophysis were examined before proton therapy and within 3 years after the treatment. High initial level of alpha 1-antitrypsin(alpha 1-AT) and alpha 2-macroglobulin (alpha 2-MG) in the patients blood plasma as well as a decrease in alpha 1-AT activity in cerebrospinal fluid were observed. Within a year after the proton hypophysectomy activity of the proteinase inhibitors returned to the normal values in blood and cerebrospinal fluid simultaneously with clinical restoration and a decrease in content of growth hormone; their level were maintained at normal values within the last two years of observation. Estimation of alpha 1-At activity in blood plasma and cerebrospinal fluid might be used as an additional test in evaluation of the treatment course in the patients with somatotropic adenoma of hypophysis.
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Reference: Zargarova O.P., Konnova L.A., Proteinase inhibitor activity of blood plasma and cerebrospinal fluid in patients with pituitary adenomas before and after proton therapy, Voprosy meditsinskoi khimii, 1983, vol: 29(6), 96-98.
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