Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of different precursors of fatty acid biosynthesis in the brain in chronic hyperphenylalaninemia

   
Putilina F.E., Osadchaia L.M.
PubMed Id: 6146224
Year: 1984 vol: 30  issue:2  pages: 100-103
Abstract: The incorporation of 14C from 2-14C-acetate, 1-6-14C-glucose and 5-14-C-glutamate into fatty acids of brain lipids under chronic hyperphenylalaninemia (HPA) was investigated. A decrease of lipogenesis intensity was demonstrated in young rat brain. In the HPA a decrease in the labelling of fatty acids occurred due to inhibition of the enzymes of fatty acid biosynthesis and to disturbance of metabolic pathways involved in lipogenesis via acentyl-CoA.
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Reference: Putilina F.E., Osadchaia L.M., Use of different precursors of fatty acid biosynthesis in the brain in chronic hyperphenylalaninemia, Voprosy meditsinskoi khimii, 1984, vol: 30(2), 100-103.
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