Voprosy meditsinskoi khimii (ISSN 0042-8809)

Intracellular localization of fibronectin-synthesizing polyribosomes using I125 collagen

   
Belkin V.M., Zlatopol'skii A.D., Zykova T.A., Mazurov V.I.
PubMed Id: 6740988
Year: 1984 vol: 30  issue:2  pages: 120-125
Abstract: Interaction of 125I-collagen with fibronectin-synthesizing polyribosomes, isolated from 9 days old chicken embryos, was studied. The interaction was maximal at the ratio of 0.1 microgram 125I-collagen and 5 ou of polyribosomes. Specific reaction of 125I-collagen with fibronectin polypeptides growing on polyribosomes was estimated by means of antibodies to fibronectin inhibiting the complex formation of polyribosomes-125I-collagen. The antibodies were shown to decrease the reaction rate of total polyribosomes (free and membrane-bound) with 125I-collagen by 25.4% and of free polyribosomes - by 6.7%. The data obtained suggest that fibronectin is synthesized mainly on polyribosomes, bound with the membranes of endoplasmic reticulum.
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Reference: Belkin V.M., Zlatopol'skii A.D., Zykova T.A., Mazurov V.I., Intracellular localization of fibronectin-synthesizing polyribosomes using I125 collagen, Voprosy meditsinskoi khimii, 1984, vol: 30(2), 120-125.
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