Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of various periods of starvation on the character of exhibited changes of energy metabolism in the rat liver during the administration of phenobarbitol and corn oil

   
Solov'ev N.V., Vavilin V.A., Panov A.V.
PubMed Id: 6740991
Year: 1984 vol: 30  issue:2  pages: 139-142
Abstract: Alterations in content of long-chain acyl-CoA and value of phosphate potential (PP) were studied in liver tissue after administration of phenobarbital and corn oil into rats, starved within 4 hrs and 12 hrs before the experiment. As compared with the 4 hrs period, starvation within 12 hrs caused an accumulation of acyl-CoA and a decrease in PP (ATP/ADP X Pi) in liver tissue. The same alterations in the patterns studied were found after administration of corn oil. However, the 12 hrs starvation amplified distinctly the effect of oil administration on the content of acyl-CoA and on the PP value. Phenobarbital, administered simultaneously with the oil, removed completely the effect of corn oil on the patterns studied during the both periods of starvation, but it caused only slight influence on the starvation induced alterations in acyl-CoA and PP. The data obtained suggest that within the two periods of starvation studied it has been possible to differentiate the unspecific effects of starvation and the alterations induced by specific agents.
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Reference: Solov'ev N.V., Vavilin V.A., Panov A.V., Effect of various periods of starvation on the character of exhibited changes of energy metabolism in the rat liver during the administration of phenobarbitol and corn oil, Voprosy meditsinskoi khimii, 1984, vol: 30(2), 139-142.
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