Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of a diet with various amounts of essential fatty acid on the fatty acid spectrum of lipids in the kidneys in spontaneously hypertensive rats

   
Markov K.M., Atrokhov V.V.
PubMed Id: 6740995
Year: 1984 vol: 30  issue:2  pages: 47-52
Abstract: Fatty acid composition of phospholipids and triglycerides was studied by means of gas chromatography in kidney of rats with spontaneous hypertension, kept on rations containing various amounts of essential fatty acids. Deficiency of essential fatty acids caused an increase in content of oleic acid (18:1 omega 9) and of its metabolite--eucosetrienic acid (20:3 omega 9). Feeding of the animals with large amounts of linoleic (18:2 omega 6) and linoleic (18:3 omega 3) acids led to an increase of their content in kidney lipids as well as to elevation of prostaglandin precursors level. With an increase in deficiency of linoleic acid activity of delta 5-desaturation of its derivatives was decreased. Decrease in the rate of arterial pressure was observed in those spontaneously hypertensive rats, in kidney of which the content of linoleic, linoleic acids and eucosepentanic acid of the linoleic species (20:5 omega 3) was increased after the alimentary treatments.
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Reference: Markov K.M., Atrokhov V.V., Effect of a diet with various amounts of essential fatty acid on the fatty acid spectrum of lipids in the kidneys in spontaneously hypertensive rats, Voprosy meditsinskoi khimii, 1984, vol: 30(2), 47-52.
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