Voprosy meditsinskoi khimii (ISSN 0042-8809)

Urinary excretion of toxic peptides in patients with thermal burns

   
Salomatin V.V., Lifshits R.I.
PubMed Id: 6474936
Year: 1984 vol: 30  issue:3  pages: 120-124
Abstract: A fraction of toxic ninhydrin-positive substances was isolated from urine of healthy persons and of the patients with acute burn toxemia using a multi-step technique, which involved ion exchange chromatography on Dowex resins, gel filtration on Sephadex G-15 and ultrafiltration on Diaflo UM-0.5. The daily excretion of the substances was about 4-fold higher in the patients as compared with healthy persons. The fraction contained basic peptides with molecular masses of 500-2,000 daltons. The total toxicity of these peptide was higher by an order of magnitude in the patients with burns as compared with healthy persons.
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Reference: Salomatin V.V., Lifshits R.I., Urinary excretion of toxic peptides in patients with thermal burns, Voprosy meditsinskoi khimii, 1984, vol: 30(3), 120-124.
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