Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of peptides in the pathology of the nervous system

Kryzhanovskiĭ G.N.
PubMed Id: 6089430
Year: 1984 vol: 30  issue:3  pages: 68-73
Abstract: There are presented data, obtained by the author and his colleagues in the investigations of the neuropeptides participating in different forms of the experimental CNS pathology. It is shown, that the purified brain fractions, extracted from the rats suffering from the vestibulopathia , induced or by hyperactivation (formation of the generator of pathologically enhanced excitation, GPEE) or coagulation of the Deiter 's nucleus under the conditions of the intracisternal or intraventricular injection resulted in the muscle's tone changes in rats-recipients. These changes represent by themselves the fragments of vestibulopathia rotation syndrome. The described effect is specific towards the localisation side of GPEE: "rightside" and "leftside" brain extractions cause the muscle's tone in the accordance with the direction of the rotation syndrome. Peptides, extracted from the left and right part of the healthy bull's brain cause changes of the muscle's tone in the accordance with the side (the lateralisation effect). Fragments of the AKTH4-7 and lysil-vasopressin produce the extension of the duration of the activity GPEE formed in the spinal cord. Synthetic hexapeptide normally causing the strengthening of the natural lateralisation of the muscle's tone may reactivate the GPEE at the early stage after its clinical disappearance (according to the electrographic data). The presented and any of the other literary data allow to make a general conclusion of the peptide's role played in the mechanisms of the occurrence, maintenance and elimination the pathological processes in the central nervous system.
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Reference: Kryzhanovskiĭ G.N., The role of peptides in the pathology of the nervous system, Voprosy meditsinskoi khimii, 1984, vol: 30(3), 68-73.