Voprosy meditsinskoi khimii (ISSN 0042-8809)

Characteristics of glucose metabolism in rats with different preferences for alcohol

   
Lelevich V.V., Ostrovskiĭ I.M., Lukashik N.K.
PubMed Id: 6095527
Year: 1984 vol: 30  issue:4  pages: 32-36
Abstract: Rats preferring ethanol were distinct from water-consuming animals in a decreased level of immunoreactive insulin im blood serum as well as in glucokinase activity of liver tissue. Per oral loading with glucose, 4 g/kg of body mass, enabled to detect a difference in the sugar phosphorylation via hexokinase and glucokinase reactions as well as the dissimilar sensitivity of the insulin system to glucose in the ethanol-, water-consuming and intermediate animals. Ethanol-consuming rats were more resistant to the effect of starvation during 48 hrs. The data obtained suggest that the characteristic properties of glucose metabolism in ethanol-consuming rats appear to be responsible for increased consumption of ethanol, which is used as optimal energy source, metabolized via pathways which did not involve the glycolytic pathway.
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Reference: Lelevich V.V., Ostrovskiĭ I.M., Lukashik N.K., Characteristics of glucose metabolism in rats with different preferences for alcohol, Voprosy meditsinskoi khimii, 1984, vol: 30(4), 32-36.
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