Voprosy meditsinskoi khimii (ISSN 0042-8809)

Alcohol dehydrogenase in the blood of healthy people and in patients with chronic alcoholism

   
Usatenko M.S., Fedurina M.A., Boĭkiĭ I.V., Borodkin I.S.
PubMed Id: 6396942
Year: 1984 vol: 30  issue:5  pages: 33-37
Abstract: Activity of alcohol dehydrogenase (ADH) was estimated using highly sensitive spectrophotometric procedure with p-nitrose dimethylaniline as a substrate in blood serum of control healthy persons without a history of alcohol abuse and of the patients with chronic alcoholism. The ADH activity in the control group was about 0.55 +/- 0.04 microM/min/L and in the patients it was 2.5-5-fold higher. A direct correlation was found between the ADH activity and duration of alcohol abuse. In the patients with alcohol abstention syndrome the activity of ADH was 4.2-fold higher as compared with controls. During the remission, from 2 months up to 5 years, the enzymatic activity decreased, but was still distinctly higher than the control values.
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Reference: Usatenko M.S., Fedurina M.A., Boĭkiĭ I.V., Borodkin I.S., Alcohol dehydrogenase in the blood of healthy people and in patients with chronic alcoholism, Voprosy meditsinskoi khimii, 1984, vol: 30(5), 33-37.
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