Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of myocardial ischemia on the ATPase system

Shkolovoĭ V.V.
PubMed Id: 6152084
Year: 1984 vol: 30  issue:5  pages: 41-43
Abstract: Preferential inhibition of Mg2+-dependent ATPase as compared with Ca2+-ATPase was found in homogenate, mitochondria and sarcoplasmic reticulum of rabbit and rat myocardium during development of ischemia in vitro. The specific alterations in the ATPase activity, observed in various organelles, apparently reflect the dissimilar rates of partial reactional inhibition in ATPase complexes and do not occur due to alterations in electrolyte microcirculation. Inhibition of the ATPase activity in organelles under ischemic conditions might be responsible for deterioration of their functions.
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Reference: Shkolovoĭ V.V., Effect of myocardial ischemia on the ATPase system, Voprosy meditsinskoi khimii, 1984, vol: 30(5), 41-43.