Voprosy meditsinskoi khimii (ISSN 0042-8809)

Calcium-dependent regulation of NAD-isocitrate dehydrogenase in the rat heart mitochondria

   
Larionov N.P., Kolykhalova I.V.
PubMed Id: 6528524
Year: 1984 vol: 30  issue:5  pages: 87-89
Abstract: Ions of Ca2+ (0.1-20 mumoles) regulated the activity of mitochondrial NAD-isocitrate dehydrogenase (isocitrate: NAD-oxidoreductase decarboxylating, EC 1.1.1.41) from rat heart altering the enzyme affinity for isocitrate. Under conditions of maximal activation by Ca2+ (20 mumoles) S0,5 was decreased from 282 down to 125 mumoles, Vmax was not altered. The calmodulin inhibitor trifluoperazine did not affect the Vmax, S0.5 and the Hill coefficient of the enzyme.
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Reference: Larionov N.P., Kolykhalova I.V., Calcium-dependent regulation of NAD-isocitrate dehydrogenase in the rat heart mitochondria, Voprosy meditsinskoi khimii, 1984, vol: 30(5), 87-89.
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