Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of lethal and superlethal doses of gamma-irradiation on the lysosomal enzyme activity in radio-sensitive and radio-resistant tissues in the rat

   
Alekseev G.I., Korovkin B.F., Mikhaleva N.P., Fedotov G.M.
PubMed Id: 6528527
Year: 1984 vol: 30  issue:5  pages: 95-98
Abstract: Activities of acid phosphatase and cathepsin D were studied in liver, spleen tissues and in blood serum of Wistar male rats with a body mass of 180-200 g within various periods after total gamma-irradiation using 137Cs (1.9 Gr/min) at doses of 7.5 and 30 Gr. Acid phosphatase was maximally activated in the non-sedimented fraction of spleen within 72 hrs at the dose of 7.5 Gr; activity of cathepsin D was decreased in the fraction and exceeded the control values only within 11 days. Activity of both enzymes was decreased in the fraction of precipitate. In liver tissue the enzymatic activity was only slightly altered at the dose used. The dose of 30 Gr altered the acid phosphatase activity both in spleen and liver tissues; the enzymatic activity was increased in non-sedimented fraction and--decreased in precipitate. In blood serum the acid phosphatase activity increased gradually up to the animal death.
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Reference: Alekseev G.I., Korovkin B.F., Mikhaleva N.P., Fedotov G.M., Effect of lethal and superlethal doses of gamma-irradiation on the lysosomal enzyme activity in radio-sensitive and radio-resistant tissues in the rat, Voprosy meditsinskoi khimii, 1984, vol: 30(5), 95-98.
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