Voprosy meditsinskoi khimii (ISSN 0042-8809)

Immunological study of the identity of cytochrome P-448 in the mouse and rat liver after induction with 3-methylcholanthrene

   
Mishin V.M., Guliaeva L.F., Mishina D.V., Gutkina N.I.
PubMed Id: 6442038
Year: 1984 vol: 30  issue:5  pages: 98-102
Abstract: As shown by means of Ouchterlony double immunodiffusion technique after induction with 3-methyl cholanthrene the antibodies towards cytochrome P-448 from rat liver tissue developed a clear-cut precipitation line with homologous antigen and interacted also with cytochrome P-448 from mice liver tissue although the precipitation was less distinct. Antibodies towards mice liver cytochrome P-448 reacted also with the rat liver cytochrome P-448 but less distinctly as compared with the mice cytochrome. At the same time, these antibodies inhibited similarly the benz(a)-pyrene-hydroxylase reaction, catalyzed by both mice and rat cytochromes P-448. Partial immunological identity appears to occur in the cytochromes studied. Role of total antigenic determinants in enzymatic reactions catalyzed by cytochrome P-448 is discussed.
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Reference: Mishin V.M., Guliaeva L.F., Mishina D.V., Gutkina N.I., Immunological study of the identity of cytochrome P-448 in the mouse and rat liver after induction with 3-methylcholanthrene, Voprosy meditsinskoi khimii, 1984, vol: 30(5), 98-102.
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