Voprosy meditsinskoi khimii (ISSN 0042-8809)

Protein-synthesizing apparatus of the rat liver and placenta during damage of the biomembrane by tetrachloromethane and the administration of methylxanthines

   
Gubskii Iu.I., Radzinskii V.E., Smal'ko P.Ia., Korniushina T.V.
PubMed Id: 6084894
Year: 1984 vol: 30  issue:6  pages: 57-61
Abstract: Treatment of rats with tetrachloromethane was accompanied by a decrease in total ribosomal material, an increase in free, unbound with membranes, polyribosomal fraction and marked decrease in 14C-leucine and 3H-orotate incorporation into proteins and RNA of liver and placenta cells. Administration of methylxanthines--euphylline and trental protected the protein-synthesizing apparatus of hepatocytes and placenta from the damaging effects of tetrachloromethane. The role of microsomal monooxygenase system in tetrachloromethane activation and in impairment of cAMP-dependent regulation of translation process under conditions of xenobiotic-induced cell injury are discussed.
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Reference: Gubskii Iu.I., Radzinskii V.E., Smal'ko P.Ia., Korniushina T.V., Protein-synthesizing apparatus of the rat liver and placenta during damage of the biomembrane by tetrachloromethane and the administration of methylxanthines, Voprosy meditsinskoi khimii, 1984, vol: 30(6), 57-61.
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