Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolic effect of gutimine on the myocardial tissue in blood loss

   
Boiarinov G.A., Shvets N.A., Peretiagin S.P., Khvorov N.V., Trifonova L.V.
PubMed Id: 3920825
Year: 1985 vol: 31  issue:1  pages: 54-58
Abstract: A rate of hemorrhage accounted for 31 mg/kg in 80 adult dogs premedicated with promedol and atropine. After circular-hemic hypoxia caused by the hemorrhage, single intravenous administration of gutimine (35-40 mg/kg) transformed the carbohydrate metabolism in heart muscle: activated glycolysis and accelerated the rate of its products oxidation, maintained the free amino acids concentration at the level similar to that of intact animals, reduced the rate of creatine phosphate synthesis.
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Reference: Boiarinov G.A., Shvets N.A., Peretiagin S.P., Khvorov N.V., Trifonova L.V., Metabolic effect of gutimine on the myocardial tissue in blood loss, Voprosy meditsinskoi khimii, 1985, vol: 31(1), 54-58.
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