Voprosy meditsinskoi khimii (ISSN 0042-8809)

In vivo activity of drug-metabolizing enzymes in various pathological conditions

   
Krakovskiĭ M.E., Ashirmetov A.Kh.
PubMed Id: 3984279
Year: 1985 vol: 31  issue:1  pages: 76-79
Abstract: Activity of enzymes, metabolizing drugs, was studied in acute kidney insufficiency and acute purulent peritonitis of rabbits using antipyrine test. In these pathological states the antipyrine half-life was increased and clearance was decreased, thus demonstrating the inhibition of drug-metabolizing enzymes. The data obtained suggest that the antipyrine test may exhibit the rate of drug metabolism in pathological conditions.
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Reference: Krakovskiĭ M.E., Ashirmetov A.Kh., In vivo activity of drug-metabolizing enzymes in various pathological conditions, Voprosy meditsinskoi khimii, 1985, vol: 31(1), 76-79.
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