Voprosy meditsinskoi khimii (ISSN 0042-8809)

Stability of tissue plasminogen activator

Liutova L.V., Andreenko G.V., Shimonaeva E.E.
PubMed Id: 3920826
Year: 1985 vol: 31  issue:1  pages: 97-99
Abstract: Stability of the tissue activator plasminogen was studied in various experimental conditions in vitro. The enzyme did not loss its activity after 3 hrs incubation and 7-fold dilution with physiological saline. Blood plasma, added to the tissue activator plasminogen preparation, decreased twice the enzyme activity even without preincubation. In blood plasma, obtained within 1 min after intravenous administration of the activator preparation, inhibition of the enzyme occurred during all the period of incubation and it was more pronounced.
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Reference: Liutova L.V., Andreenko G.V., Shimonaeva E.E., Stability of tissue plasminogen activator, Voprosy meditsinskoi khimii, 1985, vol: 31(1), 97-99.