Voprosy meditsinskoi khimii (ISSN 0042-8809)

Comparative study of the properties of dicoumarin and its compounds with heparin

   
Kudriashov B.A., Liapina L.A., Zvereva E.G.
PubMed Id: 2408377
Year: 1985 vol: 31  issue:2  pages: 79-83
Abstract: After a single administration (intramuscular or per os) of a complex dicoumarin-heparin into rats its hypocoagulation effect exceeded both in the rate and duration the effect of an equimolar doses of dicoumarin. After an intramuscular administration into rats the complex exhibited the hypocoagulation effect within 55 hrs, dicoumarin--within 31 hr. The hypocoagulation effect of the heparin-dicoumarin complex was maintained within 36 hrs, and the effect of dicumarol--within 14 hrs after administration per os.
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Reference: Kudriashov B.A., Liapina L.A., Zvereva E.G., Comparative study of the properties of dicoumarin and its compounds with heparin, Voprosy meditsinskoi khimii, 1985, vol: 31(2), 79-83.
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