Voprosy meditsinskoi khimii (ISSN 0042-8809)

Blood levels of glycosylated hemoglobin and ATP in diabetes mellitus in children

   
Kniazev I.A., Vakhrusheva L.L., Chesnokova T.T., Sergeeva N.A., Demidova L.V.
PubMed Id: 4024534
Year: 1985 vol: 31  issue:3  pages: 67-71
Abstract: To elucidate possible role of alterations in levels of glycosylated hemoglobin and ATP of blood in pathogenesis of diabetic impairments, 29 children with insulin-dependent diabetes mellitus were studied. In these children the blood content of the glycosylated hemoglobin was distinctly increased simultaneously with a decrease in ATP level. The alterations were especially distinct in the children the parents of which suffered from ischemic heart disease, myocardial infarction, insult, hypertension, diabetes mellitus. Development of diabetes mellitus in these children was characterized by the most severe manifestations (especially frequent and severe diabetic lesions, distinct decreases in secretion of insulin and in efficiency of the hormone). A hypothesis is discussed on possible importance of accelerated glycosylation of proteins and of a decrease in ATP synthesis for development of diabetic lesions.
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Reference: Kniazev I.A., Vakhrusheva L.L., Chesnokova T.T., Sergeeva N.A., Demidova L.V., Blood levels of glycosylated hemoglobin and ATP in diabetes mellitus in children, Voprosy meditsinskoi khimii, 1985, vol: 31(3), 67-71.
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