Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of prethrombin I and prostaglandin E2 on thrombin-stimulated aggregation of rat platelets

   
Strukova S.M., Petrova L.N., Kireeva E.G., Rtishcheva G.V., Liubimov V.S.
PubMed Id: 3861024
Year: 1985 vol: 31  issue:3  pages: 99-103
Abstract: Effect of inactive precursor of alpha-thrombin--prethrombin (Pre-I) and prostaglandin (PGE2) on aggregation of washed rat platelets induced by alpha-thrombin was studied. Pre-I inhibited dose-dependently the alpha-thrombin-induced platelet aggregation. K1 values for Pre-I of high and low affinity binding sites were equal to 0.9.10(-8) M and 0.56.10(-6) M, respectively. PGE2 inhibited the alpha-thrombin-induced aggregation after simultaneous addition and within 5 and 15 min of incubation with PGE2. Preincubation of platelets with alpha-thrombin within 15 min prevented the PGE2-induced aggregation but preincubation of platelets with Pre-I within 15 min did not influence the platelet aggregation, induced by PGE2.
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Reference: Strukova S.M., Petrova L.N., Kireeva E.G., Rtishcheva G.V., Liubimov V.S., Effect of prethrombin I and prostaglandin E2 on thrombin-stimulated aggregation of rat platelets, Voprosy meditsinskoi khimii, 1985, vol: 31(3), 99-103.
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