Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of various infusion media and solutions on the kallikrein-kinin system of human plasma

   
Dotsenko V.L., Morozova N.A., Iarovaia G.A.
PubMed Id: 3931350
Year: 1985 vol: 31  issue:4  pages: 116-121
Abstract: Activities of prekallikrein and Hageman factor (factor XII) were studied in some natural and artificial infusion media: polyglukine, rheoglumane, gemodes, polypher, gelatinol, saline; in solutions for parenteral nutrition--hydrolysate of casein, aminopeptide, aminokrovine, glucose solutions as well as in 10% NaCl and novocain. All the solutions studied did not affect the purified preparations of prekallikrein, but some of them activated partially purified preparations of Hageman factor. However, all these solutions, except of Ringer solution, activated Hageman factor and prekallikrein in human blood serum. Activation of prekallikrein appears to occur via the active form of Hageman factor. Among the solutions studied casein hydrolysate, 5% glucose, gelatinol and novocain exhibited the highest stimulating effect on Hageman factor and prekallikrein. Possible mechanisms of the activation are discussed.
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Reference: Dotsenko V.L., Morozova N.A., Iarovaia G.A., Effect of various infusion media and solutions on the kallikrein-kinin system of human plasma, Voprosy meditsinskoi khimii, 1985, vol: 31(4), 116-121.
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