Voprosy meditsinskoi khimii (ISSN 0042-8809)

Adrenergic regulation of adenylate cyclase activity in the myocardium of rats of different ages

   
Kil'chitskiĭ O.K.
PubMed Id: 4049794
Year: 1985 vol: 31  issue:4  pages: 91-93
Abstract: The mechanism of regulation of adenylate cyclase activity has been studied in adult and old rats. The basal and fluoride-stimulated adenylate cyclase activity was found to remain unchanged, while the epinephrine-stimulated enzyme activity rised in myocardium of adult and old rats. In chemical denervation the basal and stimulated activity of adenylate cyclase increased irrespective of age, the basal and epinephrine-stimulated activity of the enzyme was significantly higher in old rats. The age-related differences in regulation of myocardial adenylate cyclase appear to be determined by changes in receptor-mediated properties of adenylate cyclase complex. This phenomenon is responsible for peculiarities of the humoral regulation of the heart functions during ageing.
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Reference: Kil'chitskiĭ O.K., Adrenergic regulation of adenylate cyclase activity in the myocardium of rats of different ages, Voprosy meditsinskoi khimii, 1985, vol: 31(4), 91-93.
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