Voprosy meditsinskoi khimii (ISSN 0042-8809)

Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A

   
Pravdina N.F., Veselovskaia T.V., Smirnov V.D., Galegov G.A.
PubMed Id: 4090358
Year: 1985 vol: 31  issue:5  pages: 123-125
Abstract: Deoxyadenylylguanosine (dAdG, 0.2-0.4 mM), affecting the RNA polymerase activity, caused inhibition of transcription of the influenza A virus in presence of precursor AdG by 50-60% and a 80-85% inhibition in absence of the precursor. The inhibitor exhibited its effect independently on the time of addition into an incubation mixture. Addition of 0.5 mM inhibitor into a cultural medium inhibited reproduction of the influenza A virus in a culture of chicken embryonal fibroblasts.
Download PDF:
Reference: Pravdina N.F., Veselovskaia T.V., Smirnov V.D., Galegov G.A., Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A, Voprosy meditsinskoi khimii, 1985, vol: 31(5), 123-125.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)