Voprosy meditsinskoi khimii (ISSN 0042-8809)

Baygon (2-isopropoxyphenyl-N-methyl carbamate) activation of enzymatic deamination of 2-phenyl-ethylamine

Zeinalov T.A.
PubMed Id: 4090367
Year: 1985 vol: 31  issue:5  pages: 60-64
Abstract: Carbamate-containing pesticides, particularly baygon, might alter the activity of monoamine oxidase (MAO) in vivo. Baygon was found to stimulate selectively the deamination of 2-phenylethylamine, which is a specific substrate of MAO of the B type; the stimulating effect of baygon was reversible. Kinetic studies showed that the stimulation of the enzyme in presence of baygon of the competitive type. A selective inhibitor of MAO of the B type deprenyl might prevent the impairments of the central nervous system, which are observed in the baygon intoxication. Estimation of the MAO activity in blood thrombocytes may be used as a new biochemical test in diagnosis of intoxications caused by pesticides.
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Reference: Zeinalov T.A., Baygon (2-isopropoxyphenyl-N-methyl carbamate) activation of enzymatic deamination of 2-phenyl-ethylamine, Voprosy meditsinskoi khimii, 1985, vol: 31(5), 60-64.