Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of thrombin and prostaglandins E and F on various indices of carbohydrate metabolism in human platelets

   
Makarov S.A., Kudriavtseva G.V., Kolotilova A.I.
PubMed Id: 3867194
Year: 1985 vol: 31  issue:5  pages: 68-71
Abstract: After incubation of intact thrombocytes with prostaglandins E2 and F2 alpha stimulation of glucose-6-phosphate dehydrogenase and glutathione reductase activities as well as an increase in the rate of sedoheptulose-7-phosphate accumulation were found. Thrombin inhibited the glucose-6-phosphate dehydrogenase activity by 30% in these thrombocytes. Addition of thrombin, following the incubation of thrombocytes with prostaglandins, removed the activating effect of the prostaglandins on the pentosephosphate pathway reactions, inhibited glutathione reductase and lactate dehydrogenase.
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Reference: Makarov S.A., Kudriavtseva G.V., Kolotilova A.I., Effect of thrombin and prostaglandins E and F on various indices of carbohydrate metabolism in human platelets, Voprosy meditsinskoi khimii, 1985, vol: 31(5), 68-71.
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