Voprosy meditsinskoi khimii (ISSN 0042-8809)

The role of pyridine nucleotide cofactors in the reaction of microsomal N-demethylation under normal conditions and in tumor pathology

   
Komov V.P., Firsova V.I., Vennikas O.R., Sinakevich N.V.
PubMed Id: 4090379
Year: 1985 vol: 31  issue:6  pages: 132-135
Abstract: Functions of pyridine nucleotide cofactors NADPH and NADH in N-demethylation of amidopyrine were studied under conditions of normal and malignant states. Contribution of NADH-specific transfer of electrons to microsomal N-demethylation was gradually augmented in the sequence: microsomes from liver tissue of rats with Zajdela hepatoma--microsomes of ascites hepatocytes. In this sequence both synergic effect of these cofactors and the rate of N-demethylcation, if NADH was used as a cofactor, were increased.
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Reference: Komov V.P., Firsova V.I., Vennikas O.R., Sinakevich N.V., The role of pyridine nucleotide cofactors in the reaction of microsomal N-demethylation under normal conditions and in tumor pathology, Voprosy meditsinskoi khimii, 1985, vol: 31(6), 132-135.
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