Voprosy meditsinskoi khimii (ISSN 0042-8809)

Complexes of monoclonal immunoglobulins of various classes with albumin and alpha 1-proteinase inhibitor

   
Kotova T.S., German G.P., Chernokhvostova E.V.
PubMed Id: 3879044
Year: 1985 vol: 31  issue:6  pages: 46-50
Abstract: Ability of monoclonal immunoglobulins (IgG, IgA, IgM and IgD) to develop complexes with albumin and alpha 1-proteinase inhibitor (alpha 1-PI) was studied using methods of immunoelectrophoresis, cross immunoelectrophoresis and immunoselection. High of proteins, producing complexes with albumin, was found among monoclonal IgA, IgM and IgG; alpha 1-PI formed complexes mainly with IgA and IgM. In healthy volunteers complexes of blood serum proteins were not found. Albumin and alpha 1-PI developed complexes most often with various molecules of monoclonal immunoglobulins. Ability to produce complexes did not depend on the type of the paraprotein.
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Reference: Kotova T.S., German G.P., Chernokhvostova E.V., Complexes of monoclonal immunoglobulins of various classes with albumin and alpha 1-proteinase inhibitor, Voprosy meditsinskoi khimii, 1985, vol: 31(6), 46-50.
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