Voprosy meditsinskoi khimii (ISSN 0042-8809)

Interaction of acrylates with the microsomal oxidation system in the rat liver

   
Kotlovskiĭ Yu.V., Bekerev V.E., Bachmanova G.I., Ivanov V.V.
PubMed Id: 4090391
Year: 1985 vol: 31  issue:6  pages: 74-77
Abstract: Esters of acrylic and methacrylic acids (methyl acrylate, methyl methacrylate, butyl acrylate, butyl methacrylate) binding with cytochrome P-450 in rat liver microsomes, formed the spectral complexes of the first order with maximal extinction at 381-388 nm and minimal--at 416-425 nm. Dimethylaniline, used as a classical substrate of oxidation in reactions catalyzed by cytochrome P-450, inhibited the complexes formation by the mixed type. Acrylates increased the oxygen consumption and NADPH oxidation in rat liver microsomes.
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Reference: Kotlovskiĭ Yu.V., Bekerev V.E., Bachmanova G.I., Ivanov V.V., Interaction of acrylates with the microsomal oxidation system in the rat liver, Voprosy meditsinskoi khimii, 1985, vol: 31(6), 74-77.
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