Voprosy meditsinskoi khimii (ISSN 0042-8809)

Thiamine diphosphate level and metabolism in allergic myocarditis and treatment with peloid

   
Leus N.F.
PubMed Id: 3953005
Year: 1986 vol: 32  issue:1  pages: 119-122
Abstract: Enzymatic systems involved in thiamin metabolism were studied in experimental allergic myocarditis. Development of inflammation in myocardium was accompanied by a distinct activation of thiamin pyrophosphatase which catalyzed the most important step responsible for deterioration of the coenzyme functions. The stabilizing effect of peloid on the intracellular pool and compartmentalization of thiamin in myocarditis involved equilibration of the anabolic and catabolic reactions in the coenzyme metabolism, mainly due to selective inhibition of the thiamin pyrophosphatase activity stimulated under these conditions.
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Reference: Leus N.F., Thiamine diphosphate level and metabolism in allergic myocarditis and treatment with peloid, Voprosy meditsinskoi khimii, 1986, vol: 32(1), 119-122.
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