Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in the lipid levels of the liver, plasma, aorta and cholesterol esterase activity of the rat liver during exposure to tetrachloromethane

   
Dolgov A.V., Dushkin M.I., Morozov A.V., Morozova I.Yu.
PubMed Id: 3953013
Year: 1986 vol: 32  issue:1  pages: 55-58
Abstract: Content of cholesterol esters was increased 2.3-fold, triglycerides--4.7-fold, phospholipids--1.5-fold in liver tissue of CCl4-treated rats. The increase in the content of cholesterol esters and triglycerides correlated with a decrease in activity of lysosomal cholesterol esterase from liver tissue. After CCl4 intoxication content of free cholesterol was decreased 2.1-fold, free fatty acids--2-fold, phospholipids--2.3-fold, triglycerides--1.75-fold in blood. In aorta an increase in content of cholesterol esters and triglycerides was found to be 2-fold as well as activation of the cytosolic cholesterol esterase was noted. The data obtained suggest that intoxication with CCl4 affected the accumulation of cholesterol esters in the arterial wall.
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Reference: Dolgov A.V., Dushkin M.I., Morozov A.V., Morozova I.Yu., Changes in the lipid levels of the liver, plasma, aorta and cholesterol esterase activity of the rat liver during exposure to tetrachloromethane, Voprosy meditsinskoi khimii, 1986, vol: 32(1), 55-58.
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