Voprosy meditsinskoi khimii (ISSN 0042-8809)

Properties of muscle glycerol-3-phosphate dehydrogenase in rabbits with Brown-Pearce carcinoma

   
Litvinenko L.T., Khomiakova L.L., Gaevskaia V.A.
PubMed Id: 3705512
Year: 1986 vol: 32  issue:2  pages: 28-32
Abstract: Specific activity of glycerol-3-phosphate dehydrogenase, estimated in direct and reverse reactions, was decreased, as compared with normal state, without any alterations in the ratio of activities, in muscle homogenates of rabbits with Brown-Pearce carcinoma. The enzymatic activity was decreased by an order of magnitude in homogenates of the tumor as compared with muscle homogenates of the tumor-bearing animals simultaneously with relative stimulation of the reverse reaction. Specific activity of the crystalline enzyme from muscles of tumor-bearing animals was decreased as compared with normal tissues but the ratio of activities was 2-fold increased due to the reverse reaction. In the carcinoma activity of one of the three enzyme fractions, obtained after isoelectrofocusing, was similar to the control values; in the second fraction the ratio of activities was decreased due to inhibition of the direct reaction, the third fraction was inactive. Amino acid composition of crystalline glycerol-3-phosphate dehydrogenase, isolated from tumor-bearing animals, was different in content of 5 amino acids from the enzyme amino acid composition of controls, thus suggesting the structural differences of the proteins from these fractions.
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Reference: Litvinenko L.T., Khomiakova L.L., Gaevskaia V.A., Properties of muscle glycerol-3-phosphate dehydrogenase in rabbits with Brown-Pearce carcinoma, Voprosy meditsinskoi khimii, 1986, vol: 32(2), 28-32.
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