Voprosy meditsinskoi khimii (ISSN 0042-8809)

Characteristics of fatty acid composition of phosphatidyl cholines and sphingomyelins of low-density lipoproteins in the plasma of native inhabitants of Chukotka

   
Gerasimova E.N., Levachev M.M., Perova N.V., Nikitin Yu.P., Ozerova I.N., Kulakova S.N., Medvedev F.A., Torchovskaya T.I., Scherbakova I.A., Astakhova T.I.
PubMed Id: 3705519
Year: 1986 vol: 32  issue:2  pages: 66-72
Abstract: Contents of cholesterol, triglycerides, high density lipoproteins (HDL) cholesterol as well as phospholipid and fatty acid compositions of phosphatidyl cholines and sphingomyelins in low density lipoproteins (LDL) were studied in blood plasma of Chukot aborigenes--Eskimos as compared with Moscow inhabitants. In Eskimos content of HDL cholesterol was higher but concentration of cholesterol and triglycerides was lower in blood plasma. In LDL concentration of sphingomyelins was increased and fatty acid composition of phosphatidyl cholines and sphingomyelins was altered where amount of polyunsaturated fatty acids was elevated (20:5 + 22:5 + 22:6). The specific characteristics of the LDL phospholipids observed in Eskimos might be responsible for the higher liquid properties of the surface monolayer in the lipoproteins; this alteration might be important for the lipoprotein properties and transformation as well as for the properties of membrane-bound enzymes, for synthesis of thromboxane and prostacyclins.
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Reference: Gerasimova E.N., Levachev M.M., Perova N.V., Nikitin Yu.P., Ozerova I.N., Kulakova S.N., Medvedev F.A., Torchovskaya T.I., Scherbakova I.A., Astakhova T.I., Characteristics of fatty acid composition of phosphatidyl cholines and sphingomyelins of low-density lipoproteins in the plasma of native inhabitants of Chukotka, Voprosy meditsinskoi khimii, 1986, vol: 32(2), 66-72.
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