Voprosy meditsinskoi khimii (ISSN 0042-8809)

Metabolism of essential fatty acids and prostaglandins in the rat liver in chronic alcoholic intoxication

   
Buko V.U.
PubMed Id: 3085345
Year: 1986 vol: 32  issue:2  pages: 89-92
Abstract: Patterns of essential fatty acids and of prostaglandins metabolism were studied in liver tissue of rats which consumed 5% solution of ethanol as a single source of drinking material within 3, 6 and 9 months. Deficiency of essential fatty acids and a decrease in the content of prostaglandins occurred during development of chronic alcohol intoxication. Activity of PGE2 synthetase was decreased within 3 and 9 months and the activity of PGF2 alpha synthetase--within 9 months of the experiment. Activity of linoleyl-CoA-desaturase was decreased similarly in all the systems studied. The decrease in prostaglandins content found in liver tissue after long-term consumption of ethanol was due both to a deterioration in accessibility of the substrate for prostaglandin synthetase and to the decrease in activity of prostaglandin synthetases.
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Reference: Buko V.U., Metabolism of essential fatty acids and prostaglandins in the rat liver in chronic alcoholic intoxication, Voprosy meditsinskoi khimii, 1986, vol: 32(2), 89-92.
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