Voprosy meditsinskoi khimii (ISSN 0042-8809)

Distribution of subfractions of high-density lipoproteins during their separation according to hydrated density and particle size

   
Shcherbakova I.A., Perova N.V., Metel'skaia V.A., Anufrieva N.V., Olfer'ev A.M., Nechaev A.S.
PubMed Id: 3705522
Year: 1986 vol: 32  issue:2  pages: 93-101
Abstract: Distribution of high density lipoprotein (HDL) subfractions was studied by means of gradient ultracentrifugation depending on their hydration density and using electrophoresis in gradient polyacrylamide gel according to the particles size. 53 men were examined, where 43 patients were impaired with ischemic heart disease and with atherosclerosis of coronary arteries documented by angiography. In all the patients with ischemic heart disease and dislipoproteinemias distribution of the HDL particles was altered towards a decrease in amount of HDL2b particles; at the same time, loading with cholesterol of the HDL3 subfraction was lowered. The alterations in the subfraction spectrum and composition of HDL observed in the patients with the ischemia and coronary atherosclerosis appear to exhibit the atherogenous impairments in cholesterol elimination from arterial wall.
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Reference: Shcherbakova I.A., Perova N.V., Metel'skaia V.A., Anufrieva N.V., Olfer'ev A.M., Nechaev A.S., Distribution of subfractions of high-density lipoproteins during their separation according to hydrated density and particle size, Voprosy meditsinskoi khimii, 1986, vol: 32(2), 93-101.
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