Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of alpha-tocopherol on glutamic acid metabolism and nicotinamide coenzyme levels in hepatocytes

   
Iakhnina D.N., Agabekova I.I.
PubMed Id: 2873684
Year: 1986 vol: 32  issue:3  pages: 48-51
Abstract: Activity of enzymes participating in metabolism of glutamate and content of nicotinamide nucleotides was studied in rat liver tissue within 24 hrs after intramuscular administration of alpha-tocopheryl acetate at doses of 30 mg and 300 mg per kg of body mass. Excess of the vitamin was responsible for a decrease in the ratio NAD+/NADH in cytosol, for stimulation of glutamate dehydrogenase reaction, for a decrease of aspartate aminotransferase activity in mitochondria and of alanine aminotransferase activity in cytosol as well as for an increase of NADPH content.
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Reference: Iakhnina D.N., Agabekova I.I., Effect of alpha-tocopherol on glutamic acid metabolism and nicotinamide coenzyme levels in hepatocytes, Voprosy meditsinskoi khimii, 1986, vol: 32(3), 48-51.
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