Voprosy meditsinskoi khimii (ISSN 0042-8809)

Removal of lipoprotein complexes of cholesterol from plasma using silochromes

   
Andrianova I.P., Zuevskii V.V., Rabovskii A.B., Tsybul'skaia M.V., Nikitin Iu.S.
PubMed Id: 3014739
Year: 1986 vol: 32  issue:3  pages: 55-57
Abstract: Industrial silicates, silochromes, proved to be effective sorbents of cholesterol lipoprotein complexes in blood in vitro. Silochrome SH-1.5 with a diameter of pores of 180-200 nm and a capacity of 12-14 mg of cholesterol per 1 g of the sorbent exhibited the best efficiency in isolation of the complexes. At the same time, maximal unspecific binding of blood plasma proteins was observed in the systems with silochrome SH-3 with a diameter of pores of 60 nm. By use of silochrome SH-1.5 for plasmosorption the content of cholesterol was decreased from 3,600 mg/l down to 2,150 mg/l, i.e. by 40%, in blood plasma of a rabbit with experimental hypercholesterolemia.
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Reference: Andrianova I.P., Zuevskii V.V., Rabovskii A.B., Tsybul'skaia M.V., Nikitin Iu.S., Removal of lipoprotein complexes of cholesterol from plasma using silochromes, Voprosy meditsinskoi khimii, 1986, vol: 32(3), 55-57.
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