Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339

   
Dushkin M.I., Dolgov A.V.
PubMed Id: 3727478
Year: 1986 vol: 32  issue:3  pages: 98-101
Abstract: Injection of Triton WR 1339 into Wistar rats caused a marked increase in contents of free and ester-bound cholesterol, triglycerides, phospholipids and free fatty acids in tissues and a decrease in the activity of lecithin: cholesterol acyltransferase in blood. An increase in concentration of cholesterol esters in tissues was due to a decrease in activity of lysosomal cholesteryl esterase in vivo and in vitro and to an increase in non-sedimentable activities of acid phosphatase, beta-galactosidase and cholesteryl esterase. The decrease in proteolytic degradation of cholesterol esters was accompanied by an increase in the activity of tissue cytoplasmic cholesteryl esterase and by a decrease in activity of acyl-CoA: cholesterol O-acyltransferase in liver tissue.
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Reference: Dushkin M.I., Dolgov A.V., Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339, Voprosy meditsinskoi khimii, 1986, vol: 32(3), 98-101.
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