Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in and pharmacological correction of oxidative phosphorylation in regional kidney ischemia

   
Chumakov V.N., Krupenikova L.I.
PubMed Id: 3765503
Year: 1986 vol: 32  issue:4  pages: 86-90
Abstract: Respiratory and phosphorylating capacities of kidney mitochondria were distinctly decreased within early (1.5 hr) and late (1 day) postischemic periods after long-term (2-3 hrs) ischemia of rat kidney. Preadministration of adenine (ADP, AMP) and pyridine (NAD) nucleotides into the animals prevented the decreases, while vitamin E, heparin, trifluoroperazine or aminazine proved to be ineffective. Depletion of mitochondrial nucleotide pool, which occurred during long-term ischemia of kidney and were maintained within the post-ischemic period, appears to be responsible for impairment of oxidative phosphorylation.
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Reference: Chumakov V.N., Krupenikova L.I., Changes in and pharmacological correction of oxidative phosphorylation in regional kidney ischemia, Voprosy meditsinskoi khimii, 1986, vol: 32(4), 86-90.
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