Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of the prekallikrein-kallikrein system and characteristics of its regulation in various allergies

   
Nenasheva N.M., Dotsenko V.L., Goriachkina L.A., Iarovaia G.A.
PubMed Id: 3640571
Year: 1986 vol: 32  issue:5  pages: 106-111
Abstract: Activity of kallikrein and content of prekallikrein were estimated in blood serum of 34 patients with atopy and of 17 patients with urticaria by means of the chromatographic procedure. In these patients activity of alpha 1-proteolytic inhibitor (alpha 1-PI) and alpha 2-macroglobulin (alpha 2-MG) was studied. At the acute period of pollinosis activation of the kallikrein-kinin system was found, which correlated with the disease aggravation. During specific immunotherapy of the patients with atopy activation of the kallikrein-kinin system occurred, which depended on the total concentration of allergen administered. At the same time, activation of the kallikrein-kinin system, observed under conditions of urticaria, was most distinct in the patients with chronic relapsing urticaria and was related to the degree of the disease aggravation. Preparations of proteinase inhibitors analogous to contrical were only short-term effective in chronic relapsing urticaria. In the patients with distinct aggravation of pollinosis inhibitory activity of alpha 2-MG was markedly increased which occurred apparently as a result of blood pachyemia simultaneously with activation of the kallikrein-kinin system. Distinct increase in the alpha 1-PI activity was not found in the patients with pollinosis and urticaria even at the step of pronounced aggravation. Phenotyping of the inhibitor in 10 patients with a marked decrease in its activity enabled to find 6 persons exhibiting the heterozygous genotype with a defect allele.
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Reference: Nenasheva N.M., Dotsenko V.L., Goriachkina L.A., Iarovaia G.A., Activity of the prekallikrein-kallikrein system and characteristics of its regulation in various allergies, Voprosy meditsinskoi khimii, 1986, vol: 32(5), 106-111.
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