Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of bromocriptine on 3H-dopamine uptake in hypothalamic synaptosomes of intact and adrenalectomized rats

   
Iatsyk M.I.
PubMed Id: 3776119
Year: 1986 vol: 32  issue:5  pages: 60-62
Abstract: Intensity of 3H-dopamine uptake in hypothalamic synaptosomes was similar both in intact rats and in the animals which received a single administration of bromocriptine at a dose of 5 mg/kg within 4 hrs. Within 4 days after the drug administration incorporation of the label was increased 1.22-fold and 1.28-fold in intact and adrenalectomized rats, respectively. Alterations in dopamine uptake in hypothalamic synaptosomes caused by bromocriptine appear to be one of dopaminergic-dependent effects of the drug in the animal brain structures.
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Reference: Iatsyk M.I., Effect of bromocriptine on 3H-dopamine uptake in hypothalamic synaptosomes of intact and adrenalectomized rats, Voprosy meditsinskoi khimii, 1986, vol: 32(5), 60-62.
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