Voprosy meditsinskoi khimii (ISSN 0042-8809)

Fibronectin fragmentation unmasks the activity stimulating DNA and RNA biosynthesis in granulation tissue cells in vitro

   
Zlatopol'skii A.D., Zaidenberg M.A., Berman A.E., Mazurov V.I., Karelin A.A.
PubMed Id: 2437701
Year: 1987 vol: 33  issue:1  pages: 116-118
Abstract: Human blood plasma fibronectin decreased slightly the incorporation of precursors into nucleic acids of granulation tissue culture cells. A slight fragmentation of fibronectin, where the fragments with 180-200 kD molecular mass were developed, led to occurrence of the activity 2-fold stimulating the DNA synthesis. After more effective proteolysis using plasmin and trypsin the stimulating effect of fibronectin fragments on synthesis of nucleic acids maintained and constituted 165 +/- 12% and 127 +/- 7% for DNA and RNA, respectively.
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Reference: Zlatopol'skii A.D., Zaidenberg M.A., Berman A.E., Mazurov V.I., Karelin A.A., Fibronectin fragmentation unmasks the activity stimulating DNA and RNA biosynthesis in granulation tissue cells in vitro, Voprosy meditsinskoi khimii, 1987, vol: 33(1), 116-118.
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