Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of thymectomy on activity of key enzymes of gluconeogenesis in the rat liver

   
Podosinnikov I.S., Zozuliakova S.V., Chukhlovina M.L., Polushkina L.I., Zalkind L.G.
PubMed Id: 3033899
Year: 1987 vol: 33  issue:1  pages: 29-33
Abstract: Activities of key enzymes of gluconeogenesis--phosphoenolpyruvate carboxykinase, fructose-1,6-diphosphatase, glucose-6-phosphatase as well as the content of glycogen were studied in liver tissue of thymectomized rats. Gluconeogenesis was inhibited in liver tissue of these rats. As thymus and adrenal cortex are firmly related, the inhibition of gluconeogenesis in liver tissue of thymectomized rats appears to occur due to a decrease in the glucocorticoid activating effect followed the inhibition of adrenal cortex functions and absence of thymus hormones directly responsible for carbohydrate metabolism.
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Reference: Podosinnikov I.S., Zozuliakova S.V., Chukhlovina M.L., Polushkina L.I., Zalkind L.G., Effect of thymectomy on activity of key enzymes of gluconeogenesis in the rat liver, Voprosy meditsinskoi khimii, 1987, vol: 33(1), 29-33.
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